Blood Lines
by Donald Metcalf
Contents
| Preface | xiii |
| Introduction | 1 |
| The Novel Mouse: Opening Remarks and Initial Investigations | 5 |
| Hematopoietic Subpopulations, Their Detection and Regulation | 39 |
| Analysis of Hematopoietic Tissues Using Semi-solid Cultures | 57 |
| Analyzing Semi-solid Cultures | 83 |
| Assessing Proliferative and Self-renewal Capacity and Data Presentation | 107 |
| The Importance and Design of Long-term Survival Studies | 123 |
| Histological Examination | 131 |
| Transplantation Tests | 151 |
| Diseases Involving Hematopoietic Tissues | 167 |
|
Some basic biology
T-lymphoid leukemia (also termed thymic lymphoma, non-thymic lymphoma) B-lymphoid leukemias Plasmacytomas Reticulum cell sarcoma (RCS type A) (histiocytic sarcoma) Myeloid leukemia Erythroleukemia Diseases with excess cell proliferation Naturally-occurring hyperplasias Growth factor-induced hyperplasias GM-CSF G-CSF IL-3 Leukemia Inhibitory Factor (LIF) IL-6 Flt-3 ligand Erythropoietin Comment Mice with decreased hematopoietic cell production or function G-CSF GM-CSF M-CSF IL-3 IL-5 Erythropoietin Thrombopoietin Regulators active on lymphoid populations Dysplastic states Comments Aplastic states Hematopoietic diseases due to loss of intracellular inhibitors CIS SOCS-1 SOCS-3 Autoimmune disease Concluding comments |
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| Additional Analyses | 211 |
| Applying Closure | 217 |
| References | 227 |
AlphaMed Press is grateful to AMGEN for an unrestricted educational grant in support of the publication of Blood Lines.
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